The largest and longest study ever made on this question has been published: http://jama.ama-assn.org/cgi/content/full/2008.600 Vitamins C and E don't prevent heart attacks, and E is associated with hemorrhagic stroke. Another bogus study using racemic alpha tocopherol instead of high gamma mixed tocopherols and tocotrienols as well as all trans beta carotene instead of mixed cis and trans beta carotene in the Wyeth Centrum multiple capsule. And this in the context of vitamin K insufficient diets, high carbohydrate intakes, and highly refined heated damaged Omega-6 see oils. Only a Standard American Diet eater would be stupid enough to be a subject of such a study, IMO. Wyeth is not to be trusted, IMO. These are the same 'fine' folks who botched ERT in women and still seek to force it on the population as the only mode of ERT, IMO. Taking racemeic alpha tocopherol lower gamma tocopherol thus likely lowering overall antioxidant activity and vitamin K serum levels. If you take vitamin E take a high gamma formulation plus a high dose vitamin K2 supplement with vitamin C with flavoniods, and r-alpha lipoic acid the effect is likely good. Also drop the refined Omega-6 oils, simple sugars, most grains product except perhaps oats the various brans, and germ depending on your glucose tolerance, processed foods, grilled foods, then add in dark green veggies, cold water wild fish intake, organic beef, berries, unheated nuts and seeds plus of other selection of other unrefined foods and then see what happens. This is my view............Trig